InterPAD - DETAILS

3-dimethylallyl-4,4'-dihydroxy-6-methoxychalcone, licochalcone A

No.	Title	Href
1	Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Environ Toxicol. 2018 Dec;33(12):1237-1244. doi: 10.1002/tox.22630.	`Click`
2	Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells. Oncol Lett. 2017 Mar;13(3):1695-1701. doi: 10.3892/ol.2017.5614.	`Click`

No.

Title

Href

Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of MKK4/JNK and uPA expression. Environ Toxicol. 2018 Dec;33(12):1237-1244. doi: 10.1002/tox.22630.

Click

Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells. Oncol Lett. 2017 Mar;13(3):1695-1701. doi: 10.3892/ol.2017.5614.

Click

Name	Licochalcone A
PubChem CID	5318998
Molecular Weight	338.4g/mol
Synonyms	3-dimethylallyl-4,4'-dihydroxy-6-methoxychalcone, licochalcone A
Formula	C₂₁H₂₂O₄
SMILES	CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O
InChI	1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+
InChIKey	KAZSKMJFUPEHHW-DHZHZOJOSA-N
CAS Number	58749-22-7
ChEMBL ID	CHEMBL139702
ChEBI ID	CHEBI:174541
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	GuangHuoXiang
Use Part	Aerial Parts
Habitat	GuangDong, HaiNan
Flavor	Pungent
Meridian Tropism	Spleen, Stomach, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Lamiaceae 　　　　　-->Genus: Pogostemon 　　　　　　-->Species: Pogostemon cablin

Chineses Pinyin	GanCao
Use Part	Root, Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, NeiMengGu, GanSu, XinJiang
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

Chineses Pinyin	JiXueTeng
Use Part	Stem
Habitat	GuangXi
Flavor	Bitter, Sweet
Meridian Tropism	Liver, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Spatholobus 　　　　　　-->Species: Spatholobus suberectus

Chineses Pinyin	ZhiGanCao
Use Part	Root, Rhizome Of Prepared Liauorice Root
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, XinJiang, ShanDong
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

Chineses Pinyin	HuangGanCao
Use Part	Root, Rhizome
Habitat	XinJiang, NeiMengGu, NingXia, GanSu, ShanXi
Flavor	Sweet
Meridian Tropism	Heart, Lung, Stomach, Spleen

Chineses Pinyin	ZhangGuoGanCao
Use Part	Root, Rhizome
Habitat	NeiMengGu, GanSu, XinJiang
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza inflata

Pair Name	Licochalcone A, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
Gene Regulation	Down-regulation	Expression	MAP2K4	hsa6416
	Down-regulation	Expression	MAPK8	hsa5599
	Down-regulation	Expression	PLAU	hsa5328
In Vitro Model	SK-HEP-1	Liver and intrahepatic bile duct epithelial neoplasm	Homo sapiens (Human)	CVCL_0525
In Vitro Model	Huh-7	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_0336
Result	These findings first revealed the synergistic effects of LicA and Sor cotreatment against human HCC cells, further suggesting that beneficial effects on tumor regression could be confirmed through prospective clinical trials.

Pair Name	Licochalcone A, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	IFI27	hsa3429
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
In Vitro Model	MKN45	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0434
Result	LCA alone or in combination with 5-FU may have significant anticancer effects on gastric cancer cells